It purely depends on your needs. You can for sure setup a Shopify store all by yourself, but it wont be extensible. For customization of the Shopify store you would need a developer who can tweak the back end as per your needs. If you want to go ahead without a developer, Shopify has many resources like Documentations, Blogs, 24 by 7 customer support to ease the process.
The majority of work that needs a helping hand is centered around Theme Customization. This is the tricky part, where you need to have basic understanding of HTML and CSS. Further down the line you would want to customize your product pages, category pages, home page, or add payment options. All of these needs can be fulfilled by a developer who can make your store customer ready.
But we at Cedcommerce have a solution for you, where you would not need to hire developer and spend bucks. We are offering a Shopify Free Store Setup Service that will cover all your customization work without having to pay anything. We will cover Store Development to Theme Customization and all this for free, without any more info hidden charges. We will dedicate 2 to 3 Working days towards setup of store for each merchant. If you plan to open a Shopify Store, we are all geared to save your money, and get you started.